The gene for a human cholesterol receptor contains 18 exons that encode 5 domains in the protein.

Exons 2-6 comprise the domain for the binding site for cholesterol.

The next 8 exons comprise a domain homologous to the mouse hormone epidermal growth factor (EGF). A similar domain is also found in many other polypeptides, including 3 blood-clotting proteins.

Other exons specify 3 domains that perform specific functions.