Methods of Determining Allele Frequencies from Data on Genotypes

A. Counting Alleles
Genotype  1/1  1/Δ32  Δ32/Δ32  Total
Number of individuals  79  20  1  100
Number of 1 alleles  158  20  0  178
Number of Δ32 alleles  0  20  2  22
Total number of alleles  158  40  2  200
   Frequency of CCR5l in sample: 178/200 = 0.89 = 89%
   Frequency of CCR5-Δ32 in sample: 22/200 = 0.11 = 11%
       
B. From Genotype Frequencies
Genotype  1/1  1/Δ32  Δ32/Δ32  Total
Number of individuals  79  20  1  100
Genotype frequency  79/100 = 0.79  20/100 = 0.20  1/100 = 0.01  1.00
   Frequency of CCR51 in sample: 0.79 + (0.5)0.20 = 0.89
   Frequency of CCR5-Δ32 in sample: (0.5)0.20 + 0.01 = 0.11