synteny_testing.html 05_23-synteny

Cells from different organisms can be fused in culture by somatic cell hybridization to form a hybrid cell with two nuclei called a heterokaryon; the nuclei can fuse to form a synkaryon in which chromosomes from from one of the two parental species are gradually lost.

A panel of synkaryons with mostly mouse chromosomes and a few human chromosomes can be used to associate a particular gene product with a specific chromosome.

A synteny testing example: how can products A, B, C, D be mapped to chromosomes?
- Product A can be assigned to chromosome 5.
- Product B can be assigned to chromosome 3.
- Product C is not on any of the chromosomes 1-7.
- Product D can be assigned to chromosome 1.