RFLP fragments from many chromosomes were used to map the locus of type 1 neurofibromatosis (NF1), an autosomal dominant disorder.

NF1 patients exhibit a 1.9-kb RFLP fragment that segregates with other RFLP marker that had been assigned to chromosome 17.

The NF1 locus is subsequently mapped to a region near the centromere of chromosome 17.